![]() Usually, patients with advanced prostate cancer have a long disease course of several years, during which they are exposed to various systemic therapies, including long-term androgen deprivation therapy (ADT), chemotherapy, and corticosteroids. Our previous work demonstrated that suboptimal NS is associated with impaired HRQoL in patients with mCRPC at the presentation of their disease (see Table S1). Well known disease-related unfavourable prognostic factors in this disease are: high Gleason score, short time interval between radical treatment and recurrence, short prostate-specific antigen (PSA) doubling time, highly elevated PSA, extensive disease volume, presence of visceral metastases, presence of neuroendocrine histology and heavy burden of symptoms. ![]() Further interventional studies focusing on therapy or prevention are warranted. Conclusions: Suboptimal NS might be an unfavorable prognostic factor for HRQoL and OS. However, when accounting for possible confounding factors, we could not prove the significant importance of NS for chosen outcomes. When compared to WN patients, those with NR and cachexia had a higher chance of worse HRQoL (OR 3.45 95% CI, and OR 4.17 95% CI, respectively), as well as shorter OS (HR 2.04 95% CI and HR 2.9 95% CI, respectively). Results: 141 patients were included into our study. We sought the prognostic role of the NS for OS and HRQoL by regression models. At enrollment, we allocated each patient into one of four NS categories: (i) well-nourished (WN), (ii) nutritional risk without sarcopenia/cachexia (NR), (iii) sarcopenia, or (iv) cachexia. ![]() Methods: We conducted a prospective observational study in mCRPC patients. We hypothesized that patients’ NS at the presentation of mCRPC is prognostic for health-related quality of life (HRQoL) and overall survival (OS). Purpose: Prognostic role of nutritional status (NS) in patients with metastatic castrate-resistant prostate cancer (mCRPC) is unknown.
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